- Title
- Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk
- Creator
- Suchy, Janina; Kłujszo-Grabowska, Ewa; Kładny, Józef; Cybulski, Cezary; Wokołorczyk, Dominika; Szymańska-Pasternak, Jolanta; Kurzawski, Grzegorz; Scott, Rodney J.; Lubiński, Jan
- Relation
- BMC Cancer Vol. 8
- Publisher Link
- http://dx.doi.org/10.1186/1471-2407-8-112
- Publisher
- BioMed Central
- Resource Type
- journal article
- Date
- 2008
- Description
- Backgroud: Patients with chronic inflammatory bowel disease (IBD) are at an increased risk of colorectal cancer (CRC) and it is estimated that one in six persons diagnosed with IBD will develop CRC. This fact suggests that genetic variations in inflammatory response genes may act as CRC disease risk modifiers. Methods: In order to test this hypothesis we investigated a series of polymorphisms in 6 genes (NOD2, DLG5, OCTN1, OCTN2, IL4, TNFα) associated with the inflammatory response on a group of 607 consecutive newly diagnosed colorectal cancer patients and compared the results to controls (350 consecutive newborns and 607 age, sex and geographically matched controls). Results: Of the six genes only one polymorphism in TNFα(-1031T/T) showed any tendency to be associated with disease risk (64.9% for controls and 71.4% for CRC) which we further characterized on a larger cohort of CRC patients and found a more profound relationship between the TNFα -1031T/T genotype and disease (64.5% for controls vs 74.7% for CRC cases above 70 yrs). Then, we investigated this result and identified a suggestive tendency, linking the TNFα -1031T/T genotype and a previously identified change in the CARD15/NOD2 gene (OR = 1.87; p = 0,02 for CRC cases above 60 yrs). Conclusion: The association of polymorphisms in genes involved in the inflammatory response and CRC onset suggest that there are genetic changes capable of influencing disease risk in older persons.
- Subject
- inflammatory bowel disease (IBD); colorectal cancer; inflammatory response genes; disease risk modifiers; gene polymorphisms
- Identifier
- http://hdl.handle.net/1959.13/41553
- Identifier
- uon:4866
- Identifier
- ISSN:1471-2407
- Language
- eng
- Full Text
- Reviewed
- Hits: 12607
- Visitors: 4602
- Downloads: 339
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT01 | Publisher version (open access) | 585 KB | Adobe Acrobat PDF | View Details Download |