- Title
- Prevalence, symptoms and risk factor profile of rumination syndrome and functional dyspepsia: a population-based study
- Creator
- Irani, Mudar Zand; Jones, Michael P.; Halland, Magnus; Herrick, Linda; Choung, Rok Seon; Loftus, Yuri A. Saito; Walker, Marjorie M.; Murray, Joseph A.; Talley, Nicholas J.
- Relation
- Alimentary Pharmacology and Therapeutics Vol. 54, Issue 11-12, p. 1416-1431
- Publisher Link
- http://dx.doi.org/10.1111/apt.16630
- Publisher
- Wiley-Blackwell Publishing
- Resource Type
- journal article
- Date
- 2021
- Description
- Background: Rumination syndrome is a functional gastroduodenal disorder characterised by effortless regurgitation of recently ingested food. Emerging evidence reports duodenal eosinophilic inflammation in a subset, suggesting a shared pathophysiology with functional dyspepsia (FD). Aim: To assess the clinical features of rumination syndrome and FD in a community-based study. Methods: We mailed a survey assessing gastrointestinal symptoms, diet and psychological symptoms to 9835 residents of Olmsted County, MN, USA in 2017-2018; diagnostic codes were obtained from linked clinical records. The two disorders were assessed as mutually exclusive in ‘pure’ forms with a separate overlap group, all compared to a control group not meeting criteria for either. Prevalence of associations, and univariate and independent associations with predictors were assessed by logistic regression. Results: Prevalence of rumination syndrome and FD were 5.8% and 7.1%, respectively; the overlap was 3.83-times more likely than expected by chance. Independent predictors for rumination (odds ratio (OR), 95% confidence interval (CI)) were female gender (1.79, 1.21-2.63), smoking (1.89, 1.28-2.78), gluten-free diet (1.58, 1.14-2.19), allergic rhinitis (1.45, 1.01-2.08) and depression (1.10, 1.05-1.16). FD was independently associated with female gender, depression, non-coeliac wheat sensitivity, migraine, irritable bowel syndrome and somatic symptoms. A similar reported efficacy (≥54%) of low fat or dairy-free diets was found with both disorders (P = 0.53 and P = 1.00, respectively). The strongest independent associations with overlapping FD and rumination syndrome were a history of rheumatoid arthritis (3.93, 1.28-12.06) and asthma (3.02, 1.44-6.34). Conclusion: Rumination syndrome overlaps with FD with a shared risk factor profile, suggesting a common pathophysiology.
- Subject
- rumination syndrome; dyspepsia; duodenal eosinophilic inflammation; risk factors; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1470464
- Identifier
- uon:48476
- Identifier
- ISSN:0269-2813
- Language
- eng
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