- Title
- Ion currents through Kir potassium channels are gated by anionic lipids
- Creator
- Jin, Ruitao; He, Sitong; Black, Katrina A.; Clarke, Oliver B.; Wu, Di; Bolla, Jani R.; Johnson, Paul; Periasamy, Agalya; Wardak, Ahmad; Czabotar, Peter; Colman, Peter M.; Robinson, Carol V.; Laver, Derek; Smith, Brian J.; Gulbis, Jacqueline M.
- Relation
- Nature Communications Vol. 13, Issue 1, no. 490
- Publisher Link
- http://dx.doi.org/10.1038/s41467-022-28148-4
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2022
- Description
- Ion currents through potassium channels are gated. Constriction of the ion conduction pathway at the inner helix bundle, the textbook gate of Kir potassium channels, has been shown to be an ineffective permeation control, creating a rift in our understanding of how these channels are gated. Here we present evidence that anionic lipids act as interactive response elements sufficient to gate potassium conduction. We demonstrate the limiting barrier to K+ permeation lies within the ion conduction pathway and show that this gate is operated by the fatty acyl tails of lipids that infiltrate the conduction pathway via fenestrations in the walls of the pore. Acyl tails occupying a surface groove extending from the cytosolic interface to the conduction pathway provide a potential means of relaying cellular signals, mediated by anionic lipid head groups bound at the canonical lipid binding site, to the internal gate.
- Subject
- ion; potassium channels; gated; anionic lipids
- Identifier
- http://hdl.handle.net/1959.13/1468165
- Identifier
- uon:48014
- Identifier
- ISSN:2041-1723
- Rights
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Language
- eng
- Full Text
- Reviewed
- Hits: 4113
- Visitors: 4170
- Downloads: 68
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 2 MB | Adobe Acrobat PDF | View Details Download |