Pathophysiology of severe asthma: We've only just started

Title: Pathophysiology of severe asthma: We've only just started
Creator: King, Gregory G.; James, Alan; Harkness, Louise; Wark, Peter A.B.
Relation: Respirology Vol. 23, Issue 3, p. 262-271
Publisher Link: http://dx.doi.org/10.1111/resp.13251
Publisher: John Wiley & Sons
Resource Type: journal article
Date: 2018
Description: Severe asthma is defined by the high treatment requirements to partly or fully control the clinical manifestations of disease. It remains a problem worldwide with a large burden for individuals and health services. The key to improving targeted treatments, reducing disease burden and improving patient outcomes is a better understanding of the pathophysiology and mechanisms of severe disease. The heterogeneity, complexity and difficulties in undertaking clinical studies in severe asthma remain challenges to achieving better understanding and better outcomes. In this review, we focus on the structural, mechanical and inflammatory abnormalities that are relevant in severe asthma.
Subject: airway inflammation; airway remodelling; pathophysiology; severe asthma; SDG 3; Sustainable Development Goals
Identifier: http://hdl.handle.net/1959.13/1466292
Identifier: uon:47496
Identifier: ISSN:1323-7799
Language: eng
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