- Title
- Azelaic acid and Melaleuca alternifolia essential oil co-loaded vesicular carrier for combinational therapy of acne
- Creator
- Bisht, Alpna; Hemrajani, Chetna; Sourirajan, Anuradha; Aljabali, Anuradha; Bakshi, Hamid A; Negi, Poonam; Tambuwala, Murtaza M; Upadhyay, Navneet; Nidhi, Prakriti; Rolta, Rajan; Rathore, Charul; Gupta, Gaurav; Dua, Kamal; Chellappan, Dinesh Kumar; Dev, Kamal
- Relation
- Therapeutic Delivery Vol. 13, Issue 1, p. 13-29
- Publisher Link
- http://dx.doi.org/10.4155/tde-2021-0059
- Publisher
- Future Science Ltd.
- Resource Type
- journal article
- Date
- 2022
- Description
- Aim: Azelaic acid (AzA), a comedolytic, antibacterial, anti-inflammatory anti-melanogenic agent, prescribed against acne vulgaris is safe on skin. Its combination with another widely used anti-acne agent, tea tree oil (EO) whose delivery is limited by volatility, instability and lipophilicity constraints was attempted. Method: Solvent injection was used to prepare AzA-EO integrated ethosomes. Result: Ethosomes were transformed into carbopol hydrogel, which exhibited pseudo-plastic properties with appreciable firmness, work of shear, stickiness and work of adhesion. The hydrogel showed better permeation and retention characteristics vis-a-vis commercial formulation (AzidermTM), when evaluated in Wistar rat skin. Further, ethosome hydrogel composite was better tolerated with no side effects. Conclusion: The findings suggests that the aforementioned strategy could be a potential treatment used for acne management.
- Subject
- agar well diffusion method; azelaic acid; broth microdilution assay; ethosomes; P. acne; skin permeation
- Identifier
- http://hdl.handle.net/1959.13/1464820
- Identifier
- uon:47119
- Identifier
- ISSN:2041-5990
- Language
- eng
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