- Title
- The Hospitalization Rate of Cerebral Venous Sinus Thrombosis before and during COVID-19 Pandemic Era: A Single-Center Retrospective Cohort Study
- Creator
- Vasaghi Gharamaleki, Maryam; Habibagahi, Maryam; Petramfar, Peyman; Poursadeghfard, Maryam; Izadi, Sadegh; Nazeri, Masoumeh; Bazrafshan, Hanieh; Bahrami, Zahra; Karimlu, Sedigheh; Shaghayegh Zafarmand, Seyedeh; Bayat, Mahnaz; Saied Salehi, Mohammad; Hooshmandi, Etrat; Lim Alvin Chew, Beng; Garcia-Esperon, Carlos; Spratt, Neil; Levi, Christopher; Borhani-Haghighi, Afshin; Worral, BBG; Coutinho, JM; Garcia-Esperon, C; Spratt, N; Levi, C; Tabrizi, Reza; Azarpazhooh, MR; Borhani-Haghighi, A; Arsang-Jang, Shahram; Barzegar, Zohreh; Fadakar, Nima; Reza Ostovan, Vahid; Rahimi-Jaberi, Abbas; Ashjazadeh, Nahid
- Relation
- Journal of Stroke and Cerebrovascular Diseases Vol. 31, Issue 7, no. 106468
- Publisher Link
- http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2022.106468
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2022
- Description
- Objectives: There are several reports of the association between SARS-CoV-2 infection (COVID-19) and cerebral venous sinus thrombosis (CVST). In this study, we aimed to compare the hospitalization rate of CVST before and during the COVID-19 pandemic (before vaccination program). Materials and methods: In this retrospective cohort study, the hospitalization rate of adult CVST patients in Namazi hospital, a tertiary referral center in the south of Iran, was compared in two periods of time. We defined March 2018 to March 2019 as the pre-COVID-19 period and March 2020 to March 2021 as the COVID-19 period. Results: 50 and 77 adult CVST patients were hospitalized in the pre-COVID-19 and COVID-19 periods, respectively. The crude CVST hospitalization rate increased from 14.33 in the pre-COVID-19 period to 21.7 per million in the COVID-19 era (P = 0.021). However, after age and sex adjustment, the incremental trend in hospitalization rate was not significant (95% CrI: -2.2, 5.14). Patients > 50-year-old were more often hospitalized in the COVID-19 period (P = 0.042). SARS-CoV-2 PCR test was done in 49.3% out of all COVID-19 period patients, which were positive in 6.5%. Modified Rankin Scale (mRS) score ≥3 at three-month follow-up was associated with age (P = 0.015) and malignancy (P = 0.014) in pre-COVID period; and was associated with age (P = 0.025), altered mental status on admission time (P<0.001), malignancy (P = 0.041) and COVID-19 infection (P = 0.008) in COVID-19 period. Conclusion: Since there was a more dismal outcome in COVID-19 associated CVST, a high index of suspicion for CVST among COVID-19 positive is recommended.
- Subject
- sinus thrombosis; stroke; COVID-19; SARS-CoV-2; prognosis; hospitalization rate; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1464376
- Identifier
- uon:46977
- Identifier
- ISSN:1052-3057
- Language
- eng
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