- Title
- Impact of risk of generalizability biases in adult obesity interventions: A meta-epidemiological review and meta-analysis
- Creator
- Beets, Michael W.; von Klinggraeff, Lauren; Burkart, Sarah; Jones, Alexis; Ioannidis, John P. A.; Weaver, R. Glenn; Okely, Anthony D.; Lubans, David; van Sluijs, Esther; Jago, Russell; Turner-McGrievy, Gabrielle; Thrasher, James; Li, Xiaoming
- Relation
- Obesity Reviews Vol. 23, Issue 2, no. e13369
- Publisher Link
- http://dx.doi.org/10.1111/obr.13369
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2022
- Description
- Biases introduced in early-stage studies can lead to inflated early discoveries. The risk of generalizability biases (RGBs) identifies key features of feasibility studies that, when present, lead to reduced impact in a larger trial. This meta-study examined the influence of RGBs in adult obesity interventions. Behavioral interventions with a published feasibility study and a larger scale trial of the same intervention (e.g., pairs) were identified. Each pair was coded for the presence of RGBs. Quantitative outcomes were extracted. Multilevel meta-regression models were used to examine the impact of RGBs on the difference in the effect size (ES, standardized mean difference) from pilot to larger scale trial. A total of 114 pairs, representing 230 studies, were identified. Overall, 75% of the pairs had at least one RGB present. The four most prevalent RGBs were duration (33%), delivery agent (30%), implementation support (23%), and target audience (22%) bias. The largest reductions in the ES were observed in pairs where an RGB was present in the pilot and removed in the larger scale trial (average reduction ES -0.41, range -1.06 to 0.01), compared with pairs without an RGB (average reduction ES -0.15, range -0.18 to -0.14). Eliminating RGBs during early-stage testing may result in improved evidence.
- Subject
- intervention; pilot; scaling; translation; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1463685
- Identifier
- uon:46806
- Identifier
- ISSN:1467-7881
- Rights
- This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2021 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
- Language
- eng
- Full Text
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