- Title
- Transdiagnostic variations in impulsivity and compulsivity in obsessive-compulsive disorder and gambling disorder correlate with effective connectivity in cortical-striatal-thalamic-cortical circuits
- Creator
- Parkes, Linden; Tiego, Jeggan; Fornito, Alex; Yücel, Murat; Aquino, Kevin; Braganza, Leah; Chamberlain, Samuel R.; Fontenelle, Leonardo F.; Harrison, Ben J.; Lorenzetti, Valentina; Paton, Bryan; Razi, Adeel
- Relation
- NeuroImage Vol. 202, Issue 15 November 2019, no. 116070
- Publisher Link
- http://dx.doi.org/10.1016/j.neuroimage.2019.116070
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2019
- Description
- Individual differences in impulsivity and compulsivity is thought to underlie vulnerability to a broad range of disorders and are closely tied to cortical-striatal-thalamic-cortical function. However, whether impulsivity and compulsivity in clinical disorders is continuous with the healthy population and explains cortical-striatal-thalamic-cortical dysfunction across different disorders remains unclear. Here, we characterized the relationship between cortical-striatal-thalamic-cortical effective connectivity, estimated using dynamic causal modelling of resting-state functional magnetic resonance imaging data, and dimensional phenotypes of impulsivity and compulsivity in two symptomatically distinct but phenotypically related disorders, obsessive-compulsive disorder and gambling disorder. 487 online participants provided data for modelling of dimensional phenotypes. These data were combined with 34 obsessive-compulsive disorder patients, 22 gambling disorder patients, and 39 healthy controls, who underwent functional magnetic resonance imaging. Three core dimensions were identified: disinhibition, impulsivity, and compulsivity. Patients’ scores on these dimensions were continuously distributed with the healthy participants, supporting a continuum model of psychopathology. Across all participants, higher disinhibition correlated with lower bottom-up connectivity in the dorsal circuit and greater bottom-up connectivity in the ventral circuit, and higher compulsivity correlated with lower bottom-up connectivity in the dorsal circuit. In patients, higher clinical severity was also linked to lower bottom-up connectivity in the dorsal circuit, but these findings were independent of phenotypic variation, demonstrating convergence towards behaviourally and clinically relevant changes in brain dynamics. Effective connectivity did not differ as a function of traditional diagnostic labels and only weak associations were observed for functional connectivity measures. Together, our results demonstrate that cortical-striatal-thalamic-cortical dysfunction across obsessive-compulsive disorder and gambling disorder may be better characterized by dimensional phenotypes than diagnostic comparisons, supporting investigation of quantitative liability phenotypes.
- Subject
- impulsivity; compulsivity; disinhibition; OCD; GD; DCM
- Identifier
- http://hdl.handle.net/1959.13/1463318
- Identifier
- uon:46700
- Identifier
- ISSN:1053-8119
- Language
- eng
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