- Title
- Analgesic use and the risk of renal cell carcinoma – Findings from the Consortium for the Investigation of Renal Malignancies (CONFIRM) study
- Creator
- Bruinsma, F. J.; Jordan, S.; Davis, I. D.; Tucker, K.; Dudding-Byth, T.; English, D. R.; Giles, G. G.; Winship, I.; Milne, R. L.; Bassett, J. K.; Severi, G.; MacInnis, R. J.; Walsh, J.; Aitken, T.; Jenkins, M.; Carroll, R.; Jefford, M.
- Relation
- Cancer Epidemiology Vol. 75, Issue December 2021, no. 102036
- Publisher Link
- http://dx.doi.org/10.1016/j.canep.2021.102036
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2021
- Description
- Purpose: The incidence of renal cell carcinoma (RCC) is rising. Use of analgesics such as non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol may affect renal function. The aim of this study was to assess associations between analgesic use and risk of RCC. Methods: A population-based case-control family design was used. Cases were recruited via two Australian state cancer registries. Controls were siblings or partners of cases. Analgesic use was captured by self-completed questionnaire. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for RCC risk associated with regular analgesic use (at least 5 times per month for 6 months or more) and duration and frequency of use. Results: The analysis included 1064 cases and 724 controls. Regular use of paracetamol was associated with an increased risk of RCC (OR 1.41, 95%CI 1.13–1.77). Regular use of NSAIDs was associated with increased risk of RCC for women (OR 1.71, 95% CI 1.23–2.39) but not men (OR 0.83, 95% CI 0.58–1.18; p-interaction=0.003). There was no evidence of a dose-response for duration of use of paracetamol (linear trend p = 0.77) and weak evidence for non- aspirin NSAID use by women (linear trend p = 0.054). Conclusion: This study found that regular use of paracetamol was associated with increased risk of RCC. NSAID use was associated with increased risk only for women.
- Subject
- renal cell carcinoma; epidemiology; analgesic use; non-steroidal anti-inflammatory drugs (NSAIDs); paracetamol; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1461513
- Identifier
- uon:46216
- Identifier
- ISSN:1877-7821
- Language
- eng
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