- Title
- An increasing incidence of upper gastrointestinal disorders over 23 years: A prospective population-based study in Sweden
- Creator
- Andreasson, Anna; Talley, Nicholas J.; Walker, Marjorie M.; Jones, Michael P.; Platts, Loretta G.; Wallner, Bengt; Kjellström, Lars; Hellström, Per M.; Forsberg, Anna; Agréus, Lars
- Relation
- The American Journal of Gastroenterology Vol. 116, Issue 1, p. 210-213
- Publisher Link
- http://dx.doi.org/10.14309/ajg.0000000000000972
- Publisher
- Wolters Kluwer Health
- Resource Type
- journal article
- Date
- 2021
- Description
- Introduction: We hypothesized that the prevalence of functional dyspepsia and gastroesophageal reflux disease in the community may be increasing. Methods: Randomly selected adults were surveyed on 4 occasions: 1988 (n = 1,151, 21–79 years, response rate [rr] = 90%), 1989 (n = 1,097, 22–80 years, rr = 87%), 1995 (n = 1,139, 20–85 years, rr = 76%), and 2011 (n = 1,175, 20–93 years, rr = 63%). Results: In functional dyspepsia, the odds of postprandial distress syndrome tripled over 23 years' follow-up (odds ratio [OR]: 3.55; 95% confidence interval [CI]: 2.60–4.84, mixed-effect regression analysis), whereas a small decrease in epigastric pain syndrome was observed (OR: 0.65, 95% CI: 0.42–1.00). The odds of reporting gastroesophageal reflux disease doubled (OR: 2.02; 95% CI: 1.50–2.73). Discussion: The underlying mechanisms behind the increase in postprandial distress syndrome and gastroesophageal reflux disease remain to be determined.
- Subject
- gastrointestinal disorders; dyspepsia; gastroesophageal reflux disease; reflux; epigastric pain syndrome
- Identifier
- http://hdl.handle.net/1959.13/1460916
- Identifier
- uon:46068
- Identifier
- ISSN:0002-9270
- Language
- eng
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