- Title
- Simulation of Intracellular Calcium Release in Heart Cells
- Creator
- Vysma, Morris; Welsh, James; Laver, Derek
- Relation
- 8th Conference on Foundations of Systems Biology in Engineering (FOBSE). Proceedings of 8th Conference on Foundations of Systems Biology in Engineering (FOBSE) (Valencia, SPAIN 15-18 October, 2019) p. 238-243
- Publisher Link
- http://dx.doi.org/10.1016/j.ifacol.2019.12.264
- Publisher
- Elsevier
- Resource Type
- conference paper
- Date
- 2019
- Description
- Cyclic calcium release and uptake in heart cells has an important role in heart rhythm and contraction, and it is known that the malregulation of calcium release is a predictor for cardiac arrhythmia. A model of this calcium release process was proposed, which consists of a large number of discrete calcium release sites, each involving stiff, stochastic, and nonlinear systems. In this paper we have developed a simulation of this calcium release model, which is parallel across the problem. The simulation is developed in a CUDA framework to be solved using GPUs. Computational efficiency is enhanced by using a DIIRK solver and taking advantage of the sparsity of the Jacobian. The output is shown to display behaviour similar to empirical observations, in particular displaying behaviour known as calcium waves.
- Subject
- nonlinear systems; biomedical systems; parallel processing; computer simulation
- Identifier
- http://hdl.handle.net/1959.13/1460294
- Identifier
- uon:45922
- Language
- eng
- Reviewed
- Hits: 315
- Visitors: 302
- Downloads: 0