Oxidative damage to sperm DNA: attack and defense

Title: Oxidative damage to sperm DNA: attack and defense
Creator: Drevet, Joel R.; Aitken, R. J.
Relation: Genetic Damage in Human Spermatozoa p. 107-117
Relation: Advances in Experimental Medicine and Biology 1166
Publisher Link: http://dx.doi.org/10.1007/978-3-030-21664-1_7
Publisher: Springer Cham
Resource Type: book chapter
Date: 2019
Description: Due to its particular “silent” metabolic state, without transcription or translation, and a low level of cytosolic protective activities, mature sperm is a cellular type of aerobic organisms particularly at risk of oxidative damage. Despite the efforts of the male genital tract to treat this problem, a subcellular compartment of the sperm, the nucleus, and consequently, the paternal DNA cannot be effectively protected. There is an accumulation of evidence that oxidative damage to sperm DNA is quite common in male infertilities/subfertilities with potential harmful impacts on reproductive success, including the transgenerational inheritance of a paternal chromosomal lot carrying mutations.
Subject: reactive oxygen species; male infertility; lipid peroxidation; oxidative DNA damage; DNA repair
Identifier: http://hdl.handle.net/1959.13/1459632
Identifier: uon:45727
Identifier: ISBN:9783030216634
Language: eng

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