- Title
- IL-25 blockade augments antiviral immunity during respiratory virus infection
- Creator
- Williams, Teresa C.; Loo, Su-Ling; Jackson, Crystal L.; Alton, Kirby; Shimkets, Richard A.; Girkin, Jason L.; Bartlett, Nathan W.; Nichol, Kristy S.; Reid, Andrew T.; Veerati, Punnam C.; Esneau, Camille; Wark, Peter A. B.; Grainge, Christopher L.; Knight, Darryl A.; Vincent, Thomas
- Relation
- Communications Biology Vol. 5, no. 415
- Publisher Link
- http://dx.doi.org/10.1038/s42003-022-03367-z
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2022
- Description
- IL-25 is implicated in the pathogenesis of viral asthma exacerbations. However, the effect of IL-25 on antiviral immunity has yet to be elucidated. We observed abundant expression and colocalization of IL-25 and IL-25 receptor at the apical surface of uninfected airway epithelial cells and rhinovirus infection increased IL-25 expression. Analysis of immune transcriptome of rhinovirus-infected differentiated asthmatic bronchial epithelial cells (BECs) treated with an anti-IL-25 monoclonal antibody (LNR125) revealed a re-calibrated response defined by increased type I/III IFN and reduced expression of type-2 immune genes CCL26, IL1RL1 and IL-25 receptor. LNR125 treatment also increased type I/III IFN expression by coronavirus infected BECs. Exogenous IL-25 treatment increased viral load with suppressed innate immunity. In vivo LNR125 treatment reduced IL-25/type 2 cytokine expression and increased IFN-β expression and reduced lung viral load. We define a new immune-regulatory role for IL-25 that directly inhibits virus induced airway epithelial cell innate anti-viral immunity.
- Subject
- IL-25; antiviral immunity; rhinovirus; asthma; bronchial epithelial cells (BECs); innate immunity; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1457497
- Identifier
- uon:45347
- Identifier
- ISSN:2399-3642
- Rights
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Language
- eng
- Full Text
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