- Title
- Role of the prorenin receptor in endometrial cancer cell growth
- Creator
- Martin, Jacinta H.; Mohammed, Riazuddin; Lumbers, Eugenie R.; Pringle, Kirsty G.; Delforce, Sarah J.; Skerrett-Byrne, David A.; de Meaultsart, Celine Corbisier; Almazi, Juhura G.; Stephens, Andrew N.; Verrills, Nicole M.; Dimitriadis, Evdokia; Wang, Yu
- Relation
- Oncotarget Vol. 13, Issue 1, p. 587-599
- Publisher Link
- http://dx.doi.org/10.18632/ONCOTARGET.28224
- Publisher
- Impact Journals
- Resource Type
- journal article
- Date
- 2022
- Description
- Endometrial cancer is the most diagnosed gynecological malignancy. Despite numerous scientific advances, the incidence and mortality rate of endometrial cancer continues to rise. Emerging evidence suggests a putative role of the (pro)renin receptor ((P)RR), in the ontogenesis of endometrial cancer. The (P)RR is implicated in breast cancer and pancreatic carcinoma pathophysiology by virtue of its role in proliferation, angiogenesis, fibrosis, migration and invasion. Thus, we aimed to investigate the functional role of the (P)RR in human endometrial cancer. We employed an siRNA-mediated knockdown approach to abrogate (P)RR expression in the endometrial epithelial cell lines; Ishikawa, AN3CA and HEC-1-A and examined cellular proliferation and viability. We also carried out a sophisticated proteomic screen to explore potential pathways via which the (P)RR is acting in endometrial cancer physiology. These data confirmed that the (P)RR is critical for endometrial cancer development, contributing to both its proliferative capacity and in the maintenance of cell viability. This is likely mediated through proteins such as MGA, SLC4A7, SLC7A11 or DHRS2, which were reduced following (P)RR knockdown. These putative protein interactions/pathways, which rely on the presence of the (P)RR, are likely to contribute to endometrial cancer progression and could therefore, represent several novel therapeutic targets for endometrial cancer.
- Subject
- (P)RR; ATP6AP2; endometrial cancer; cellular viability; cellular proliferation; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1456476
- Identifier
- uon:45233
- Identifier
- ISSN:1949-2553
- Rights
- © 2022 Martin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Language
- eng
- Full Text
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