- Title
- Nasal epithelial cells to assess in vitro immune responses to respiratory virus infection in pregnant women with asthma
- Creator
- Vanders, Rebecca L.; Hsu, Alan; Gibson, Peter G.; Murphy, Vanessa E.; Wark, Peter A. B.
- Relation
- NHMRC.455593 http://purl.org/au-research/grants/nhmrc/455593 | 455626 http://purl.org/au-research/grants/nhmrc/455626
- Relation
- Respiratory Research Vol. 20, no. 259
- Publisher Link
- http://dx.doi.org/10.1186/s12931-019-1225-5
- Publisher
- BioMed Central
- Resource Type
- journal article
- Date
- 2019
- Description
- Respiratory virus-induced asthma exacerbations occur frequently during pregnancy and are associated with adverse outcomes for mother and child. Primary nasal epithelial cells (pNECs) provide a useful method to study immune responses in pregnancy. pNECs were obtained by nasal brushings from pregnant and non-pregnant women with and without asthma. pNECS were infected in vitro with major group Rhinovirus 43 (RV43) and seasonal influenza (H3N2). Following infection, pNECs showed measurable quantities of interferon (IFN)-λ, IL-1β, IL-8, IP-10 and MIP1-α. pNECs provide a safe and effective method for studying respiratory epithelial cell responses during pregnancy.
- Subject
- pregnancy; asthma; nasal cells; respiratory infections; influenza; rhinovirus; in vitro cultures; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1455519
- Identifier
- uon:45097
- Identifier
- ISSN:1465-993X
- Rights
- © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Language
- eng
- Full Text
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