Vitamin-related phenotypic adaptation to exposomal factors: The folate-vitamin D-exposome triad

Title: Vitamin-related phenotypic adaptation to exposomal factors: The folate-vitamin D-exposome triad
Creator: Lucock, Mark
Relation: Molecular Aspects of Medicine Vol. 87, Issue October 2022, no. 100944
Publisher Link: http://dx.doi.org/10.1016/j.mam.2021.100944
Publisher: Elsevier
Resource Type: journal article
Date: 2022
Description: The biological role of two key vitamins, folic acid and vitamin D is so fundamental to life processes, it follows that their UV sensitivity, dietary abundance (both key exposomal factors) and variability in dependent genes will modify their functional efficacy, particularly in the context of maintaining the integrity and function of genome and epigenome. This article therefore examines folate and vitamin D-related phenotypic adaptation to environmental factors which vary across the human life cycle as well as over an evolutionary time-scale. Molecular mechanisms, key nutrigenomic factors, phenotypic maladaptation and evolutionary models are discussed.
Subject: exposome; vitamin D; folic acid; epigenetics; phenome; adaptation
Identifier: http://hdl.handle.net/1959.13/1452797
Identifier: uon:44510
Identifier: ISSN:0098-2997
Language: eng
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