- Title
- Asthma-COPD overlap: current understanding and the utility of experimental models
- Creator
- Tu, Xiaofan; Donovan, Chantal; Kim, Richard Y.; Wark, Peter A. B.; Horyat, Jay C.; Hansbro, Philip M.
- Relation
- NHMRC.1079187 http://purl.org/au-research/grants/nhmrc/1079187, NHMRC 1120152 http://purl.org/au-research/grants/nhmrc/1120152, NHMRC 1138402 http://purl.org/au-research/grants/nhmrc/1138402
- Relation
- European Respiratory Review Vol. 30, Issue 159, no. 190185
- Publisher Link
- http://dx.doi.org/10.1183/16000617.0185-2019
- Publisher
- European Respiratory Society (ERS)
- Resource Type
- journal article
- Date
- 2021
- Description
- Pathological features of both asthma and COPD coexist in some patients and this is termed asthma-COPD overlap (ACO). ACO is heterogeneous and patients exhibit various combinations of asthma and COPD features, making it difficult to characterise the underlying pathogenic mechanisms. There are no controlled studies that define effective therapies for ACO, which arises from the lack of international consensus on the definition and diagnostic criteria for ACO, as well as scant in vitro and in vivo data. There remain unmet needs for experimental models of ACO that accurately recapitulate the hallmark features of ACO in patients. The development and interrogation of such models will identify underlying disease-causing mechanisms, as well as enabling the identification of novel therapeutic targets and providing a platform for assessing new ACO therapies. Here, we review the current understanding of the clinical features of ACO and highlight the approaches that are best suited for developing representative experimental models of ACO.
- Subject
- asthma; experimental models; overlap; COPD; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1448945
- Identifier
- uon:43527
- Identifier
- ISSN:0905-9180
- Language
- eng
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