- Title
- BDNF-Deficient Mice Show Reduced Psychosis-Related Behaviors Following Chronic Methamphetamine
- Creator
- Manning, Elizabeth E.; Halberstadt, Adam L.; van den Buuse, Maarten
- Relation
- International Journal of Neuropsychopharmacology Vol. 19, Issue 4
- Publisher Link
- http://dx.doi.org/10.1093/ijnp/pyv116
- Publisher
- Oxford University Press
- Resource Type
- journal article
- Date
- 2016
- Description
- Background: One of the most devastating consequences of methamphetamine abuse is increased risk of psychosis. Brain-derived neurotrophic factor has been implicated in both psychosis and neuronal responses to methamphetamine. We therefore examined persistent psychosis-like behavioral effects of methamphetamine in brain-derived neurotrophic factor heterozygous mice. Methods: Mice were chronically treated with methamphetamine from 6 to 9 weeks of age, and locomotor hyperactivity to an acute D-amphetamine challenge was tested in photocell cages after a 2-week withdrawal period. Results: Methamphetamine-treated wild-type mice, but not brain-derived neurotrophic factor heterozygous mice, showed locomotor sensitization to acute 3mg/kg D-amphetamine. Qualitative analysis of exploration revealed tolerance to D-amphetamine effects on entropy in methamphetamine-treated brain-derived neurotrophic factor heterozygous mice, but not wild-type mice. Conclusions: Chronic methamphetamine exposure induces contrasting profiles of behavioral changes in wild-type and brain-derived neurotrophic factor heterozygous mice, with attenuation of behaviors relevant to psychosis in methamphetamine-treated brain-derived neurotrophic factor heterozygous mice. This suggests that brain-derived neurotrophic factor signalling changes may contribute to development of psychosis in methamphetamine users.
- Subject
- methamphetamine; brain-derived neurotrophic factor; psychosis; exploration; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1447103
- Identifier
- uon:43052
- Identifier
- ISSN:1461-1457
- Language
- eng
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