- Title
- Can Ketogenic Diet Therapy Improve Migraine Frequency, Severity and Duration?
- Creator
- Haslam, Rebecca L.; Bezzina, Aaron; Herbert, Jaimee; Spratt, Neil; Rollo, Megan E.; Collins, Clare E.
- Relation
- Healthcare Vol. 9, Issue 9, no. 1105
- Publisher Link
- http://dx.doi.org/10.3390/healthcare9091105
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2021
- Description
- Migraine is the third most common condition worldwide and is responsible for a major clinical and economic burden. The current pilot trial investigated whether ketogenic diet therapy (KDT) is superior to an evidence-informed healthy “anti-headache” dietary pattern (AHD) in improving migraine frequency, severity and duration. A 12-week randomised controlled crossover trial consisting of the two dietary intervention periods was undertaken. Eligible participants were those with a history of migraines and who had regularly experienced episodes of moderate or mildly intense headache in the previous 4 weeks. Migraine frequency, duration and severity were assessed via self-report in the Migraine Buddy© app. Participants were asked to measure urinary ketones and side effects throughout the KDT. Twenty-six participants were enrolled, and 16 participants completed all sessions. Eleven participants completed a symptom checklist; all reported side-effects during KDT, with the most frequently reported side effect being fatigue (n = 11). All completers experienced migraine during AHD, with 14/16 experiencing migraine during KDT. Differences in migraine frequency, severity or duration between dietary intervention groups were not statistically significant. However, a clinically important trend toward lower migraine duration on KDT was noted. Further research in this area is warranted, with strategies to lower participant burden and promote adherence and retention
- Subject
- migraine; ketogenic diet; anti-migraine diet
- Identifier
- http://hdl.handle.net/1959.13/1446463
- Identifier
- uon:42877
- Identifier
- ISSN:2227-9032
- Language
- eng
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