- Title
- Celastrol-loaded liquid crystalline nanoparticles as an anti-inflammatory intervention for the treatment of asthma
- Creator
- Chan, Yinghan; Ng, Sin Wi; Chellappan, Dinesh Kumar; Madheswaran, Thiagarajan; Zeeshan, Farrukh; Kumar, Pradeep; Pillay, Viness; Gupta, Gaurav; Wadhwa, Ridhima; Mehta, Meenu; Wark, Peter; Hsu, Alan; Hansbro, Nicole G.; Hansbro, Philip Michael; Dua, Kamal; Panneerselvam, Jithendra
- Relation
- International Journal of Polymeric Materials and Polymeric Biomaterials Vol. 70, Issue 11, p. 754-763
- Publisher Link
- http://dx.doi.org/10.1080/00914037.2020.1765350
- Publisher
- Taylor & Francis
- Resource Type
- journal article
- Date
- 2020
- Description
- The present study aimed to formulate celastrol into liquid crystalline nanoparticles (LCNPs) through ultrasonication to enhance its therapeutic efficacy in the treatment of asthma. The physiochemical characteristics, in-vitro release studies were determined along with molecular simulations. Celastrol-loaded LCNPs showed the mean particle size of 194.1 ± 9.78 nm and high entrapment efficiency of 99.1 ± 0.02%. TEM revealed cubical-like structure of the nanoparticles and in-vitro release study demonstrated sustained drug release. They also demonstrated significant activity in reducing IL-1β production, when evaluated using immortalized human bronchial epithelial cell lines (BCi-NS1.1), that may help alleviate the symptoms of asthma.
- Subject
- anti-inflammatory; asthma; celastrol; liquid crystalline nanoparticles; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1446183
- Identifier
- uon:42789
- Identifier
- ISSN:0091-4037
- Language
- eng
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