Oxidation of Sperm Nucleus in Mammals: A Physiological Necessity to Some Extent with Adverse Impacts on Oocyte and Offspring.

Title: Oxidation of Sperm Nucleus in Mammals: A Physiological Necessity to Some Extent with Adverse Impacts on Oocyte and Offspring.
Creator: Drevet, Joel R.; Aitken, Robert John
Relation: Antioxidants Vol. 9, Issue 2, no. 95
Publisher Link: http://dx.doi.org/10.3390/antiox9020095
Publisher: MDPI AG
Resource Type: journal article
Date: 2020
Description: Sperm cells have long been known to be good producers of reactive oxygen species, while they are also known to be particularly sensitive to oxidative damage affecting their structures and functions. As with all organic cellular components, sperm nuclear components and, in particular, nucleic acids undergo oxidative alterations that have recently been shown to be commonly encountered in clinical practice. This review will attempt to provide an overview of this situation. After a brief coverage of the biological reasons why the sperm nucleus and associated DNA are sensitive to oxidative damage, a summary of the most recent results concerning the oxidation of sperm DNA in animal and human models will be presented. The study will then attempt to cover the possible consequences of sperm nuclear oxidation on male fertility and beyond.
Subject: spermatozoa; nuclear integrity; oxidative DNA damage; putative transgenerational impacts
Identifier: http://hdl.handle.net/1959.13/1445655
Identifier: uon:42636
Identifier: ISSN:2076-3921
Language: eng
Reviewed

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