- Title
- Single-cell epigenomics in cancer: Charting a course to clinical impact
- Creator
- Bond, Danielle R.; Uddipto, Kumar; Enjeti, Anoop K.; Lee, Heather J.
- Relation
- NHMRC.GNT1143614 http://purl.org/au-research/grants/nhmrc/1143614 & ARC. DP200102903 http://purl.org/au-research/grants/arc/DP200102903
- Relation
- Epigenomics Vol. 12, Issue 13, p. 1139-1151
- Publisher Link
- http://dx.doi.org/10.2217/epi-2020-0046
- Publisher
- Future Medicine Ltd.
- Resource Type
- journal article
- Date
- 2020
- Description
- Cancer is a disease of global epigenetic dysregulation. Mutations in epigenetic regulators are common events in multiple cancer types and epigenetic therapies are emerging as a treatment option in several malignancies. A major challenge for the clinical management of cancer is the heterogeneous nature of this disease. Cancers are composed of numerous cell types and evolve over time. This heterogeneity confounds decisions regarding treatment and promotes disease relapse. The emergence of single-cell epigenomic technologies has introduced the exciting possibility of linking genetic and transcriptional heterogeneity in the context of cancer biology. The next challenge is to leverage these tools for improved patient outcomes. Here we consider how single-cell epigenomic technologies may address the current challenges faced by cancer clinicians.
- Subject
- cancer; epigenetics; intra-tumoral heterogeneity; sequencing; single-cell analysis; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1444636
- Identifier
- uon:42366
- Identifier
- ISSN:1750-1911
- Language
- eng
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