- Title
- Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition
- Creator
- Lucock, Mark; Thota, Rohith; Garg, Manohar; Martin, Charlotte; Jones, Patrice; Furst, John; Yates, Zoe; Jablonski, Nina G.; Chaplin, George; Veysey, Martin; Sutherland, Jessie M.; Beckett, Emma
- Relation
- ARC.G0188386
- Relation
- American Journal of Human Biology Vol. 30, Issue 5, no. e23166
- Publisher Link
- http://dx.doi.org/10.1002/ajhb.23166
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2018
- Description
- Objectives: The purpose of this study was (1) to elucidate any reciprocal seasonal relationship that might exist between red cell folate (RCF) and serum vitamin D3 Levels; (2) to explore whether folate-related gene variants that influence/alter DNA-thymidylate and methyl group biosynthesis modify any associations detected in objective 1; and (3) to consider whether these processes might influence reproductive success consistent with the “folate-vitamin D-UV hypothesis of skin pigmentation” evolutionary model. Methods: A large (n = 649) Australian cross-sectional study population was examined. Polymerase chain reaction (PCR)/Restriction fragment length polymorphism (RFLP) analysis was used to genotype C677T-MTHFR, C1420T-SHMT, T401C-MTHFD and 2R > 3R-TS. RCF was measured by chemiluminescent immunoassay and vitamin D2 and D3 by HPLC. Results: RCF and photosynthesized vitamin D3, but not RCF and dietary vitamin D2, exhibit a significant reciprocal association in spring and summer. Three folate genes (C677T-MTHFR, C1420T-SHMT, and 2R > 3R-TS) strengthen this effect in spring, and another (T401C-MTHFD) in summer. Effects are seasonal, and do not occur over the whole year. Conclusions: Findings are consistent with what might be required for the “folate-vitamin D-UV hypothesis of skin pigmentation” model. It suggests genetic influence in provision of one-carbon units by 5,10-methylene-H4folate, may be an important factor in what appears to be a clear seasonal relationship between vitamin D3 and folate status.
- Subject
- folate; vitamin D; red cell folate (RCF); cross-sectional studies
- Identifier
- http://hdl.handle.net/1959.13/1444372
- Identifier
- uon:42277
- Identifier
- ISSN:1042-0533
- Rights
- This is the peer reviewed version of the following article Lucock, Mark; Thota, Rohith; Garg, Manohar; Martin, Charlotte; Jones, Patrice; Furst, John; Yates, Zoe; Jablonski, Nina G.; Chaplin, George; Veysey, Martin; Sutherland, Jessie M.; Beckett, Emma. “Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition”. American Journal of Human Biology Vol. 30, Issue 5, no. e23166 (2018) which has been published in final form at http://dx.doi.org/10.1002/ajhb.23166. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of SelfArchived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
- Language
- eng
- Full Text
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