- Title
- Model-based analysis on systemic availability of co-administered cannabinoids after controlled vaporised administration
- Creator
- Liu, Zheng; Galettis, Peter; Broyd, Samantha J.; van Hell, Hendrika; Greenwood, Lisa-Marie; de Krey, Peter; Steigler, Amy; Zhu, Xiao; Schneider, Jennifer; Solowij, Nadia; Martin, Jennifer H.
- Relation
- NHMRC.APP1135054 http://purl.org/au-research/grants/nhmrc/1135054 | APP1007593 http://purl.org/au-research/grants/nhmrc/1007593 | ARC|FT110100752
- Relation
- Internal Medicine Journal Vol. 50, Issue 7, p. 846-853
- Publisher Link
- http://dx.doi.org/10.1111/imj.14415
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2020
- Description
- Background: The most important two medicinal cannabinoids are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Vaporised administration is superior due to its higher systemic availability, lower individual variability and faster drug delivery. Although it is common THC is co-administered with CBD, the influence of CBD on the pharmacokinetics, especially the systemic availability of THC after vaporised administration, is unknown. Aims: To investigate the influence of different doses of co-administered CBD on the systemic availability of THC, and to compare the availability of THC and CBD in a sample of frequent and infrequent cannabis users. Methods: The study used a randomised, double-blind, crossover placebo-controlled design. THC and/or CBD in ethanol was vaporised and inhaled. Plasma concentrations of THC and CBD were analysed. The THC data created in this study were pooled together with published THC pharmacokinetic data in order to cover all the phases of THC disposition. Population pharmacokinetic model of THC was developed based on the pooled data. The model of CBD was developed based on the data created in this study. Results: Population pharmacokinetic models of THC and CBD were developed. With concomitant inhalation of high-dose CBD, the systemic availability of THC decreased significantly. Frequent cannabis users appeared to have higher systemic availability of THC and CBD when high-dose CBD was administered. Conclusions: The results observed in this study are useful for guiding future pharmacokinetic studies of medicinal cannabinoids, and for development of dosing guidelines for medical use of cannabis in the ‘real-world’ setting.
- Subject
- cannabidiol; cannabinoid; medicinal cannabis; pharmacokinetics; population pharmacokinetics model; Δ9-tetrahydrocannabinol; population pharmacokinetics model; Δ9-tetrahydrocannabinol
- Identifier
- http://hdl.handle.net/1959.13/1442752
- Identifier
- uon:41786
- Identifier
- ISSN:1444-0903
- Rights
- Liu, Zheng; Galettis, Peter; Martin, Jennifer H.; Broyd, Samantha J.; van Hell, Hendrika; Greenwood, Lisa-Marie; de Krey, Peter; Steigler, Amy; Zhu, Xiao; Schneider, Jennifer; Solowij, Nadia. “Model-based analysis on systemic availability of co-administered cannabinoids after controlled vaporised administration”. Internal Medicine Journal Vol. 50, Issue 7, p. 846-853 (2020), which has been published in final form at http://dx.doi.org/10.1111/imj.14415.This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
- Language
- eng
- Full Text
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