- Title
- Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data.
- Creator
- Van Vulpen, Jonna K.; Sweegers, Maike G.; Peeters, Petra H. M.; Courneya, Kerry S.; Aaronson, Neil K.; Jacobsen, Paul B.; Galvão, Daniel A.; Chinapaw, Mai J.; Steindorf, Karen; Irwin, Melinda L.; Stuiver, Martijn M.; Hayes, Sandi; Griffith, Kathleen; Mesters, Ilse; Knoop, Hans; Goedendorp, Martine M.; Mutrie, Nanette; Daley, Amanda J.; McConnachie, Alex; James, Erica L.; Bohus, Martin; Thorsen, L; Schulz, K-H; Short, CE; Plotnikoff, RC; Schmidt, ME; Ulrich, CM; VAN Beurden, M; Oldenburg, HS; Sonke, GS; VAN Harten, WH; Schmitz, KH; Winters-Stone, KM; Velthuis, MJ; Taaffe, DR; VAN Mechelen, W; Kersten, MJ; Nollet, F; Wenzel, J; Newton, Robert U.; Wiskemann, J; Verdonck-DE Leeuw, IM; Brug, J; May, AM; Buffart, LM
- Relation
- Medicine and Science in Sports and Exercise Vol. 52, Issue 2, p. 303-314
- Publisher Link
- http://dx.doi.org/10.1249/mss.0000000000002154
- Publisher
- Lippincott Williams & Wilkins
- Resource Type
- journal article
- Date
- 2020
- Description
- Purpose: Fatigue is a common and potentially disabling symptom in patients with cancer. It can often be effectively reduced by exercise. Yet, effects of exercise interventions might differ across subgroups. We conducted a meta-analysis using individual patient data of randomized controlled trials (RCT) to investigate moderators of exercise intervention effects on cancer-related fatigue. Methods: We used individual patient data from 31 exercise RCT worldwide, representing 4366 patients, of whom 3846 had complete fatigue data. We performed a one-step individual patient data meta-analysis, using linear mixed-effect models to analyze the effects of exercise interventions on fatigue (z score) and to identify demographic, clinical, intervention- and exercise-related moderators. Models were adjusted for baseline fatigue and included a random intercept on study level to account for clustering of patients within studies. We identified potential moderators by testing their interaction with group allocation, using a likelihood ratio test. Results: Exercise interventions had statistically significant beneficial effects on fatigue (β = −0.17; 95% confidence interval [CI], −0.22 to −0.12). There was no evidence of moderation by demographic or clinical characteristics. Supervised exercise interventions had significantly larger effects on fatigue than unsupervised exercise interventions (βdifference = −0.18; 95% CI −0.28 to −0.08). Supervised interventions with a duration ≤12 wk showed larger effects on fatigue (β = −0.29; 95% CI, −0.39 to −0.20) than supervised interventions with a longer duration. Conclusions: In this individual patient data meta-analysis, we found statistically significant beneficial effects of exercise interventions on fatigue, irrespective of demographic and clinical characteristics. These findings support a role for exercise, preferably supervised exercise interventions, in clinical practice. Reasons for differential effects in duration require further exploration.
- Subject
- exercise; fatigue; cancer; individual patient data meta-analysis; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1439484
- Identifier
- uon:40943
- Identifier
- ISSN:0195-9131
- Rights
- This is a non-final version of an article published in final form in Van Vulpen, Jonna K.; Sweegers, Maike G.; Irwin, Melinda L.; Stuiver, Martijn M.; Hayes, Sandi; Griffith, Kathleen; Mesters, Ilse; Knoop, Hans; Goedendorp, Martine M.; Mutrie, Nanette; Daley, Amanda J.; McConnachie, Alex; Peeters, Petra H. M.; Bohus, Martin; Thorsen, L; Schulz, K-H; Short, CE; James, Erica L.; Plotnikoff, RC; Schmidt, ME; Ulrich, CM; VAN Beurden, M; Oldenburg, HS; Courneya, Kerry S.; Sonke, GS; VAN Harten, WH; Schmitz, KH; Winters-Stone, KM; Velthuis, MJ; Taaffe, DR; VAN Mechelen, W; Kersten, MJ; Nollet, F; Wenzel, J; Newton, Robert U.; Wiskemann, J; Verdonck-DE Leeuw, IM; Brug, J; May, AM; Buffart, LM; Aaronson, Neil K.; Jacobsen, Paul B.; Galvão, Daniel A.; Chinapaw, Mai J.; Steindorf, Karen. “Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data”. Published in Medicine and Science in Sports and Exercise Vol. 52, Issue 2, p. 303-314 (2020).
- Language
- eng
- Full Text
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