- Title
- Environmental Air Pollutants Inhaled during Pregnancy Are Associated with Altered Cord Blood Immune Cell Profiles
- Creator
- Gomes, Gabriela Martins Costa; Karmaus, Wilfried; Murphy, Vanessa E.; Gibson, Peter G.; Percival, Elizabeth; Hansbro, Philip M.; Starkey, Malcolm R.; Mattes, Joerg; Collison, Adam M.
- Relation
- NHMRC.1060983 http://purl.org/au-research/grants/nhmrc/1060983 | ARC DE170100226 http://purl.org/au-research/grants/arc/DE170100226
- Relation
- International Journal of Environmental Research and Public Health Vol. 18, Issue 14, no. 7431
- Publisher Link
- http://dx.doi.org/10.3390/ijerph18147431
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2021
- Description
- Air pollution exposure during pregnancy may be a risk factor for altered immune maturation in the offspring. We investigated the association between ambient air pollutants during pregnancy and cell populations in cord blood from babies born to mothers with asthma enrolled in the Breathing for Life Trial. For each patient (n = 91), daily mean ambient air pollutant levels were extracted during their entire pregnancy for sulfur dioxide (SO2), nitric oxide, nitrogen dioxide, carbon monoxide, ozone, particulate matter <10 μm (PM10) or <2.5 μm (PM2.5), humidity, and temperature. Ninety-one cord blood samples were collected, stained, and assessed using fluorescence-activated cell sorting (FACS). Principal Component (PC) analyses of both air pollutants and cell types with linear regression were employed to define associations. Considering risk factors and correlations between PCs, only one PC from air pollutants and two from cell types were statistically significant. PCs from air pollutants were characterized by higher PM2.5 and lower SO2 levels. PCs from cell types were characterized by high numbers of CD8 T cells, low numbers of CD4 T cells, and by high numbers of plasmacytoid dendritic cells (pDC) and low numbers of myeloid DCs (mDCs). PM2.5 levels during pregnancy were significantly associated with high numbers of pDCs (p = 0.006), and SO2 with high numbers of CD8 T cells (p = 0.002) and low numbers of CD4 T cells (p = 0.011) and mDCs (p = 4.43 x 10−6) in cord blood. These data suggest that ambient SO2 and PM2.5 exposure are associated with shifts in cord blood cell types that are known to play significant roles in inflammatory respiratory disease in childhood.
- Subject
- air pollutants; cord blood; asthma; prenatal risk factors; particulate matter; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1437460
- Identifier
- uon:40357
- Identifier
- ISSN:1660-4601
- Rights
- © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
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