- Title
- Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis
- Creator
- Thyssen, Jacob P.; Ahluwalia, Tarunveer S.; Paternoster, Lavinia; Ballardini, Natalia; Bergström, Anna; Melén, Erik; Chawes, Bo L.; Stokholm, Jakob; Hourihane, Jonathan O'B.; O'Sullivan, Donnchadh M.; Bager, Peter; Melbye, Mads; Bustamante, Mariona; Torrent, Maties; Esplugues, Ana; Duijts, Liesbeth; Hu, Chen; Elbert, Niels J.; Pasmans, Suzanne G. M. A.; Nijsten, Tamar E. C.; Pennell, Craig E.; Wang, Carol A.; von berg, Andrea; Standl, Marie; Schikowski, Tamara; Herberth, Gunda; Heinrich, Joachim; Lee, Young-Ae; Marenholz, Ingo; Lau, Susanne; Curtin, John A.; Simpson, Angela; Custovic, Adnan; Holt, Patrick G.; Bisgaard, Hans; Bønnelykke, Klaus
- Relation
- Allergy: European Journal of Allergy and Clinical Immunology Vol. 75, Issue 6, p. 1481-1485
- Publisher Link
- http://dx.doi.org/10.1111/all.14162
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2020
- Description
- Letter To the Editor. Atopic dermatitis (AD) is a prevalent inflammatory skin disease. Loss-of-function mutations in the filaggrin gene (FLG) represent the strongest genetic risk factor for AD, being strongly associated with early disease onset and persistence into adulthood. The epidermis of individuals with mutations in FLG is fundamentally different from normal skin being characterized by increased penetration of allergens. This meta-analysis could not confirm an interaction between cat exposure in infancy and FLG mutations on development of early-onset AD. Gene-environment interactions in AD remain largely unknown.
- Subject
- atopic dermatitis (AD); skin disease; genetic risk; allergens
- Identifier
- http://hdl.handle.net/1959.13/1436795
- Identifier
- uon:40140
- Identifier
- ISSN:0105-4538
- Language
- eng
- Reviewed
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