- Title
- The effect of NMDA-R antagonist, MK-801, on neuronal mismatch along the rat auditory thalamocortical pathway
- Creator
- Parras, Gloria G.; Valdés-Baizabal, Catalina; Harms, Lauren; Michie, Patricia T.; Malmierca, Manuel S.
- Relation
- NHMRC.APP1109283 http://purl.org/au-research/grants/nhmrc/1109283
- Relation
- Scientific Reports Vol. 10, Issue 1, no. 12391
- Publisher Link
- http://dx.doi.org/10.1038/s41598-020-68837-y
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2020
- Description
- Efficient sensory processing requires that the brain maximize its response to unexpected stimuli, while suppressing responsivity to expected events. Mismatch negativity (MMN) is an auditory event-related potential that occurs when a regular pattern is interrupted by an event that violates the expected properties of the pattern. According to the predictive coding framework there are two mechanisms underlying the MMN: repetition suppression and prediction error. MMN has been found to be reduced in individuals with schizophrenia, an effect believed to be underpinned by glutamate N-methyl-d-aspartate receptor (NMDA-R) dysfunction. In the current study, we aimed to test how the NMDA-R antagonist, MK-801 in the anaesthetized rat, affected repetition suppression and prediction error processes along the auditory thalamocortical pathway. We found that low-dose systemic administration of MK-801 differentially affect thalamocortical responses, namely, increasing thalamic repetition suppression and cortical prediction error. Results demonstrate an enhancement of neuronal mismatch, also confirmed by large scale-responses. Furthermore, MK-801 produces faster and stronger dynamics of adaptation along the thalamocortical hierarchy. Clearly more research is required to understand how NMDA-R antagonism and dosage affects processes contributing to MMN. Nonetheless, because a low dose of an NMDA-R antagonist increased neuronal mismatch, the outcome has implications for schizophrenia treatment.
- Subject
- animals; auditory cortex; dizocilpine maleate; dose-response relationship; drug; evoked potentials
- Identifier
- http://hdl.handle.net/1959.13/1434888
- Identifier
- uon:39540
- Identifier
- ISSN:2045-2322
- Language
- eng
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