- Title
- Antiproliferative effects of boswellic acids-loaded chitosan nanoparticles on human lung cancer cell line A549
- Creator
- Solanki, Neeta; Mehta, Meenu; Hansbro, Philip M.; Dua, Kamal; Dureja, Harish; Chellappan, Dinesh Kumar; Gupta, Gaurav; Hansbro, Nicole G.; Tambuwala, Murtaza M.; Aljabali, Alaa Aa; Paudel, Keshav Raj; Liu, Gang; Satija, Saurabh
- Relation
- Future Medicinal Chemistry Vol. 12, Issue 22, p. 2019-2034
- Relation
- https://www.future-science.com/doi/abs/10.4155/fmc-2020-0083
- Publisher
- Future Science
- Resource Type
- journal article
- Date
- 2020
- Description
- Aim: In the present study boswellic acids-loaded chitosan nanoparticles were synthesized using ionic gelation technique. The influence of independent variables were studied and optimized on dependent variables using central composite design. Methodology & results: The designed nanoparticles were observed spherical in shape with an average size of 67.5–187.2 nm and have also shown an excellent entrapment efficiency (80.06 ± 0.48). The cytotoxicity assay revealed enhanced cytotoxicity for drug-loaded nanoparticles in contrast to the free drug having an IC50 value of 17.29 and 29.59 μM, respectively. Flow cytometry confirmed that treatment of cells with 40 μg/ml had arrested 22.75 ± 0.3% at SubG0 phase of the cell cycle when compared with untreated A459 cells. The observed results justified the boswellic acids-loaded chitosan nanoparticles were effective due to greater cellular uptake, sustained intercellular drug retention and enhanced antiproliferative effect by inducing apoptosis.
- Subject
- bioavailability; boswellic acids; chitosan; lung cancer; nanoparticles
- Identifier
- http://hdl.handle.net/1959.13/1428001
- Identifier
- uon:38589
- Identifier
- ISSN:1756-8919
- Language
- eng
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