- Title
- Barriers and challenges in performing pharmacokinetic atudies to inform sosing in the neonatal population
- Creator
- O'Hara, Kate; Martin, Jennifer H.; Schneider, Jennifer J.
- Relation
- Pharmacy Vol. 8, Issue 1, no. 16
- Publisher Link
- http://dx.doi.org/10.3390/pharmacy8010016
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2020
- Description
- A number of barriers and challenges must be overcome in order to conduct the pharmacokinetic studies that are urgently needed to inform the selection and dosing of medication in neonates. However, overcoming these barriers can be difficult. This review outlines the common barriers researchers are confronted with, including issues with ethics approval and consent, study design for pharmacokinetic studies and the ability to measure the drug concentrations in the blood samples obtained. Strategies to overcome these challenges are also proposed.
- Subject
- neonate; pharmacokinetics; translational research; ethics; biomedical; modeling; drug
- Identifier
- http://hdl.handle.net/1959.13/1426460
- Identifier
- uon:38421
- Identifier
- ISSN:2226-4787
- Rights
- © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
- Reviewed
- Hits: 1193
- Visitors: 1417
- Downloads: 228
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 174 KB | Adobe Acrobat PDF | View Details Download |