- Title
- Blood cadmium levels as a marker for early lung cancer detection
- Creator
- Lener, Marcin R.; Reszka, Edyta; Grodzki, Tomasz; Wójcik, Janusz; Wojtyś, Małgorzata; Dębniak, Tadeusz; Cybulski, Cezary; Gronwald, Jacek; Kubisa, Bartosz; Pieróg, Jarosław; Waloszczyk, Piotr; Scott, Rodney J.; Marciniak, Wojciech; Jakubowska, Anna; Narod, Steven A.; Lubiński, Jan; Lesicka, Monika; Baszuk, Piotr; Jabłońska, Ewa; Białkowska, Katarzyna; Muszyńska, Magdalena; Pietrzak, Sandra; Derkacz, Róża
- Relation
- Journal of Trace Elements in Medicine and Biology Vol. 64, Issue March 2021, no. 126682
- Publisher Link
- http://dx.doi.org/10.1016/j.jtemb.2020.126682
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2021
- Description
- Background: We assessed whether blood cadmium levels were associated with incident lung cancer and could be used in the context of a screening program for early-stage lung cancer. Material and methods: We measured blood cadmium levels among 205 lung cancer patients and 205 matched controls. Cases and controls were matched for sex, age and smoking history (total pack-years, years since cessation for former smokers). Results: The odds ratio for those in the highest quartile of cadmium level (versus lowest) was four-fold (OR = 4.41, 95 % CI:2.01-9.67, p < 0.01). The association was present in former smokers (OR = 16.8, 95 % CI:3.96-71.2, p < 0.01), but not in current smokers (OR = 1.23, 95 % CI: 0.34-4.38) or in never smokers (OR not defined). Among former smokers, the association was present in both early- and late-stage lung cancer. Conclusion: Blood cadmium levels may be a marker to help with the early detection of lung cancer among former smokers.
- Subject
- cadmium; lung cancer; detection marker; blood cadmium; Sustainable Development Goals; SDG 7; SDG 3
- Identifier
- http://hdl.handle.net/1959.13/1426278
- Identifier
- uon:38391
- Identifier
- ISSN:0946-672X
- Rights
- © 2020 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
- Language
- eng
- Full Text
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Goal 3: Good Health and Well-Being
Goal 7: Ensure access to affordable, reliable, sustainable and modern energy
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