- Title
- A review of efferent cholinergic synaptic transmission in the vestibular periphery and its functional implications
- Creator
- Poppi, L. A.; Holt, J. C.; Lim, R.; Brichta, A. M.
- Relation
- NHMRC.APP1105110 http://purl.org/au-research/grants/nhmrc/1105110
- Relation
- Journal of Neurophysiology Vol. 123, Issue 2, p. 608-629
- Publisher Link
- http://dx.doi.org/10.1152/JN.00053.2019
- Publisher
- American Physiological Society
- Resource Type
- journal article
- Date
- 2020
- Description
- It has been over 60 years since peripheral efferent vestibular terminals were first identified in mammals, and yet the function of the efferent vestibular system remains obscure. One reason for the lack of progress may be due to our deficient understanding of the peripheral efferent synapse. Although vestibular efferent terminals were identified as cholinergic less than a decade after their anatomical characterization, the cellular mechanisms that underlie the properties of these synapses have had to be inferred. In this review we examine how recent mammalian studies have begun to reveal both nicotinic and muscarinic effects at these terminals and therefore provide a context for fast and slow responses observed in classic electrophysiological studies of the mammalian efferent vestibular system, nearly 40 years ago. Although incomplete, these new results together with those of recent behavioral studies are helping to unravel the mysterious and perplexing action of the efferent vestibular system. Armed with this information, we may finally appreciate the behavioral framework in which the efferent vestibular system operates.
- Subject
- cholinergic; cochlea; efferents; nicotinic; vestibular
- Identifier
- http://hdl.handle.net/1959.13/1426049
- Identifier
- uon:38353
- Identifier
- ISSN:0022-3077
- Language
- eng
- Reviewed
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