- Title
- Cognitive insight, medication adherence and methamphetamine cessation in people enrolled in a pharmacotherapy trial for methamphetamine use
- Creator
- Raftery, Dayle; Kelly, Peter J.; Deane, Frank P.; Carter, Gregory; Dean, Olivia M.; Lubman, Dan I.; Turner, Alyna; McKetin, Rebecca
- Relation
- NHMRC.1128147 http://purl.org/au-research/grants/nhmrc/1128147
- Relation
- Journal of Substance Abuse Treatment Vol. 130, Issue November 2021, no. 108473
- Publisher Link
- http://dx.doi.org/10.1016/j.jsat.2021.108473
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2021
- Description
- Background: The current study examined correlates of cognitive insight in people enrolled in a methamphetamine pharmacotherapy trial; whether cognitive insight at the start of the trial predicted medication adherence and reductions in methamphetamine use during the trial; and, whether insight would remain stable over the trial or improve with reductions in methamphetamine use. Methods A subset of people enrolled in a 12-week randomised placebo-controlled pharmacotherapy trial for methamphetamine dependence completed the Beck Cognitive Insight Scale, comprising subscales for Self-Reflection and Self-Certainty, at baseline (n = 152) and at week 12 (n = 79). Medication adherence was expressed as the percentage of non-missed doses measured using eCAP™ technology. Methamphetamine use days were assessed using the Timeline Followback. Results: At baseline, greater Self-Reflection was correlated with more severe methamphetamine withdrawal, and hostility, whereas Self-Certainty was correlated with less education and longer duration of methamphetamine use. No relationship was found between BCIS subscales at baseline and medication adherence (Self-Reflection b[SE] = −0.73 [0.43] p = .09; Self-Certainty b[SE] = −0.31 [0.48] p = .52,). Neither BCIS subscale was predictive of reduced methamphetamine use at 12 weeks (Self-Reflection b[SE] = 0.001 [0.01] p = .95 Self-Certainty b[SE] = −0.003 [0.01], p = .74). Self-Reflection decreased over the trial (t = 3.42, p = .001) but this was unrelated to change in methamphetamine use (Self-Reflection, b[SE] = −1.68 [1.16] p = .15) Change in methamphetamine use was found to be a significant predictor of Self-Certainty at 12 weeks (b [SE] = −2.71 [1.16] p = .02). Conclusions: We found no evidence that cognitive insight predicted medication adherence or methamphetamine reduction in people engaged in this trial. Ongoing or increased methamphetamine use predicted increased Self-Certainty at 12 weeks.
- Subject
- addiction; insight; Beck Cognitive Insight Scale; methamphetamine use; medication adherence
- Identifier
- http://hdl.handle.net/1959.13/1424455
- Identifier
- uon:38081
- Identifier
- ISSN:0740-5472
- Language
- eng
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