- Title
- Anticholinergic burden, sleep quality and health outcomes in Malaysian aged care home residents
- Creator
- Kumar, Suresh; Hasan, Syed Shahzad; Wong, Pei Se; Chong, David Weng Kwai; Kairuz, Therese
- Relation
- Pharmacy Vol. 7, Issue 4, no. 143
- Publisher Link
- http://dx.doi.org/10.3390/pharmacy7040143
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2019
- Description
- The use of anticholinergic medications by residents in aged care homes is associated with increased risk of adverse effects. These include cognitive impairment, sleep disturbances, and falls, and necessitate increased healthcare visits and the associated burden on healthcare systems. The objective of this study was to investigate associations between anticholinergic burden and health outcomes such as independence in activities for daily living, frailty, quality of life, and sleep quality. The study was conducted among residents in Malaysian aged care homes, aged 60 years and above. Anticholinergic burden was calculated using the Anticholinergic Cognitive Burden (ACB) scale. Health outcome measures included independence, assessed using the Katz Activities for Daily Living scale (Katz ADL); quality of life, assessed using the Older Peoples' Quality of Life Questionnaire (OPQOL); frailty, assessed using the Groningen Frailty Index (GFI); and sleep quality, measured using the Pittsburg Sleep Quality Index (PSQI). Just over one-third (36%) of the study population was exposed to at least one medication with anticholinergic effect. An increased anticholinergic cognitive burden was associated with frailty (p = 0.031), sleep latency (p = 0.007), and sleep disturbances (p = 0.015). Further studies are required to assess the effect of prolonged exposure to anticholinergic medications on health outcomes.
- Subject
- anticholinergics; ADL; frailty; quality of life; sleep; aged homes
- Identifier
- http://hdl.handle.net/1959.13/1414861
- Identifier
- uon:36821
- Identifier
- ISSN:2226-4787
- Rights
- This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Language
- eng
- Full Text
- Reviewed
- Hits: 3655
- Visitors: 3837
- Downloads: 190
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 233 KB | Adobe Acrobat PDF | View Details Download |