- Title
- Clinical use of SNP-microarrays for the detection of genome-wide changes in haematological malignancies
- Creator
- Berry, Nadine K.; Scott, Rodney J.; Rowlings, Philip; Enjeti, Anoop K.
- Relation
- Critical Reviews in Oncology/Hematology Vol. 142, Issue October 2019, p. 58-67
- Publisher Link
- http://dx.doi.org/10.1016/j.critrevonc.2019.07.016
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2019
- Description
- Single nucleotide polymorphism (SNP) microarrays are commonly used for the clinical investigation of constitutional genomic disorders; however, their adoption for investigating somatic changes is being recognised. With increasing importance being placed on defining the cancer genome, a shift in technology is imperative at a clinical level. Microarray platforms have the potential to become frontline testing, replacing or complementing standard investigations such as FISH or karyotype. This 'molecular karyotype approach' exemplified by SNP-microarrays has distinct advantages in the investigation of several haematological malignancies. A growing body of literature, including guidelines, has shown support for the use of SNP-microarrays in the clinical laboratory to aid in a more accurate definition of the cancer genome. Understanding the benefits of this technology along with discussing the barriers to its implementation is necessary for the development and incorporation of SNP-microarrays in a clinical laboratory for the investigation of haematological malignancies.
- Subject
- SNP-microarray; microarray; haematology; haematological malignancies
- Identifier
- http://hdl.handle.net/1959.13/1412375
- Identifier
- uon:36471
- Identifier
- ISSN:1040-8428
- Rights
- © 2019 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
- Language
- eng
- Full Text
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