- Title
- Weight-based tacrolimus trough concentrations post liver transplant
- Creator
- Liu, Zheng; Cheng, Jeffrey; Powell, Elizabeth; Macdonald, Graeme; Fawcett, Jonathan; Lynch, Stephen; Martin, Jennifer
- Relation
- Internal Medicine Journal Vol. 49, Issue 1, p. 79-83
- Publisher Link
- http://dx.doi.org/10.1111/imj.14043
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2019
- Description
- Background: Tacrolimus is one of the most widely used liver transplant medications. With the increasing number of obese patients requiring liver transplants, knowledge of the effect of body size affecting post-transplant outcomes, for example drug exposure is increasingly required. Aims: (i) To investigate whether patient body size (i.e. total bodyweight) affects trough plasma concentrations of tacrolimus when a standard mg/kg dosing regimen is used; and (ii) to investigate whether obese patients have different numbers of plasma concentrations outside the therapeutic range compared to non-obese patients in the first months after liver transplant. Methods: Using a transplant database, data tacrolimus concentrations were available for 69 patients. Tacrolimus was initially dosed at a standard 0.1 mg/kg/day after liver transplant, and adjusted to maintain a target trough concentration. Trough blood samples, phenotypic and outcome variables were analysed. Results: Trough concentrations were similar between obese and non-obese patients (P > 0.05) at each sampling day. At day 7 post-transplant, 85.7% and 79.5% of the observed plasma concentrations were outside the recommended therapeutic range for obese and non-obese patients respectively, at day 30, 52.9% and 57.4%, and at 6 months, 18.7% and 27.5%. Conclusion: In the first week post-transplant, tacrolimus trough concentrations after standard mg/kg dosing post liver transplant appear to be corrected by total bodyweight. Obese patients have a similar number of trough plasma concentrations outside the therapeutic range compared to non-obese patients.
- Subject
- tacrolimus; pharmacokinetics; body size; liver transplant
- Identifier
- http://hdl.handle.net/1959.13/1411422
- Identifier
- uon:36334
- Identifier
- ISSN:1444-0903
- Rights
- This is the peer reviewed version of the following article: Liu, Z., Cheng, J., Powell, E., Macdonald, G., Fawcett, J., Lynch, S. and Martin, J. (2019), Weight‐based tacrolimus trough concentrations post liver transplant. Intern Med J, 49: 79-83., which has been published in final form at http://dx.doi.org/10.1111/imj.14043. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
- Language
- eng
- Full Text
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