- Title
- Delayed return to estrus following treatment with the gonadotrophin-releasing hormone agonist, Lucrin® Depot, in the tammar wallaby
- Creator
- Witt, Ryan R.; Hinds, Lyn A.; Rodger, John C.
- Relation
- Theriogenology Vol. 115, p. 108-116
- Publisher Link
- http://dx.doi.org/10.1016/j.theriogenology.2018.04.029
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2018
- Description
- Gonadotrophin-releasing hormone agonists that induce a reversible contraceptive state in several marsupials have the potential to be used to synchronize estrus. We used a model macropod, the tammar wallaby (Notamacropus eugenii), to investigate whether Lucrin Depot (AbbVie), a GnRH agonist microsphere preparation, could (1) inhibit follicular development and estrus in a cycle reactivated by removal of pouch young (RPY) and (2) facilitate a synchronous return to estrus. Our results show that females reactivated with bromocriptine and RPY in early seasonal quiescence (July 2015) were inhibited by Lucrin Depot (0.125-0.5 mg kg -1, n=9) and unlike control females (n=3), did not copulate before Day 32 RPY. During the next breeding season (February 2016), the return to estrus after RPY was not delayed in animals treated with Lucrin Depot (=0.20 mg kg -1; n=12), and copulation occurred in treated and control females within the expected natural period after RPY (Day 26-33 RPY). In the following breeding season (March 2017), estrus was delayed in animals treated with Lucrin Depot (1.25 mg kg -1) on either Day 0 (Group A, n=6) or Day 10 (Group B, n=6) after RPY compared to control females (n=6). Estrus was detected in Group A between 39 and 66 days (55 ± 4.8d) and in Group B between 43 and 71 days (55.2 ± 3.9d) after RPY. In contrast, all control females underwent estrus and copulated as expected by Day 30 RPY. We conclude Lucrin Depot can inhibit ovarian follicular activity after RPY but as a standalone treatment does not result in a highly synchronous return to estrus in the tammar wallaby.
- Subject
- GnRH; reproductive technology; estrus synchronization; conservation; marsupial
- Identifier
- http://hdl.handle.net/1959.13/1411022
- Identifier
- uon:36271
- Identifier
- ISSN:0093-691X
- Language
- eng
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