- Title
- Outcomes and relapse patterns following chemotherapy in advanced Hodgkin lymphoma in the positron emission tomography era
- Creator
- Lapuz, Carminia; Enjeti, Anoop K.; O'Brien, Peter C.; Capp, Anne L.; Holliday, Elizabeth G.; Gupta, Sanjiv A.
- Relation
- Blood and Lymphatic Cancer: Targets and Therapy Vol. 8, p. 13-20
- Publisher Link
- http://dx.doi.org/10.2147/BLCTT.S160404
- Publisher
- Dove Medical Press
- Resource Type
- journal article
- Date
- 2018
- Description
- Background: This study evaluated relapse patterns and survival in advanced Hodgkin lymphoma (HL) patients treated with doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) with positron emission tomography (PET) used for staging and response assessment. Patients and methods: Patients aged 18 years or above with newly diagnosed histologically proven Stage III or IV HL treated with ABVD at Calvary Mater Newcastle from January 2005 to December 2012 were included in this study. All patients underwent pre-chemotherapy staging with 18F-fluorodeoxyglucose PET or PET/computed tomography and post-chemotherapy PET or PET/computed tomography for the assessment of response. Results: Forty-three patients were included in the study. The 5-year disease-free survival, progression-free survival and overall survival were 88%, 74% and 86%, respectively. PET complete response was seen in 35 patients (81%), and the 5-year overall survival for this group was 94%. Relapse following a PET complete response was low (three patients) and occurred predominantly at the initial sites of disease. Four of five patients with bulky disease received consolidative radiotherapy and no in-field relapses were observed. Conclusion: Advanced stage HL with a PET complete response following ABVD is associated with an excellent prognosis.
- Subject
- Hodgkin lymphoma; advanced; PET scan; chemotherapy
- Identifier
- http://hdl.handle.net/1959.13/1404937
- Identifier
- uon:35414
- Identifier
- ISSN:1179-9889
- Rights
- CC BY NC. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
- Language
- eng
- Full Text
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