- Title
- Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function
- Creator
- Wyss, Annah B.; Sofer, Tamar; Gao, Wei; Ahluwalia, Tarunveer S.; Tang, Wenbo; Oldmeadow, Christopher; Duan, Qing; de Jong, Kim; Wojczynski, Mary K.; Wang, Xin-Qun; Noordam, Raymond; Hartwig, Fernando Pires; Lee, Mi Kyeong; Holliday, Elizabeth G.; McEvoy, Mark; Attia, John R.; Terzikhan, Natalie; Nguyen, Jennifer N.; Lahousse, Lies; Latourelle, Jeanne C.; Smith, Albert Vernon; Bartz, Traci M.; Feitosa, Mary F.
- Relation
- Nature Communications Vol. 9, Issue 1
- Publisher Link
- http://dx.doi.org/10.1038/s41467-018-05369-0
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2018
- Description
- Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N = 60,552), African (N = 8429), Asian (N = 9959), and Hispanic/Latino (N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12. Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci.
- Subject
- pulmonary function; multiethnic meta-analysis; ancestry; cross-ancestry loci
- Identifier
- http://hdl.handle.net/1959.13/1403033
- Identifier
- uon:35094
- Identifier
- ISSN:2041-1723
- Rights
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
- Language
- eng
- Full Text
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