- Title
- Gelatin-albumin hybrid nanoparticles as matrix metalloproteinases-degradable delivery systems for breast cancer therapy
- Creator
- Shargh, Vahid Heravi; Hondermarck, Hubert; Liang, Mingtao
- Relation
- Nanomedicine Vol. 12, Issue 9, p. 977-989
- Publisher Link
- http://dx.doi.org/10.2217/nnm-2016-0419
- Publisher
- Future Medicine
- Resource Type
- journal article
- Date
- 2017
- Description
- Aim: To develop matrix metalloproteinase-responsive gelatin-albumin hybrid nanoparticles encapsulating a selective tropomyosin receptor kinase A (TrkA) inhibitor GNF-5837 (Gel-Alb-GNF HNPs) and to demonstrate their anticancer effects in breast cancer. Methods: Gel-Alb-GNF HNPs were prepared using a pH-controlled complexation process from cationic gelatin, dextran sulfate and albumin-bound GNF-5837. The anticancer activities of Gel-Alb-GNF HNPs were tested in a panel of subtype-specific breast cancer cell lines. Results: Gel-Alb-GNF HNPs (~130 nm) displayed excellent stability and matrix metalloproteinase-triggered drug release. Compared with GNF-5837 alone, Gel-Alb-GNF HNPs not only significantly enhanced the antiproliferative and anti-invasive effects but also restored the apoptosis of cancer cells. Conclusion: Gel-Alb-GNF HNPs may be adaptable for stand-alone therapies or used in combination with traditional chemotherapies for breast cancer treatment.
- Subject
- breast cancer; hybrid nanoparticles; matrix metalloproteinase; TrkA inhibitor
- Identifier
- http://hdl.handle.net/1959.13/1400019
- Identifier
- uon:34716
- Identifier
- ISSN:1743-5889
- Language
- eng
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