- Title
- Accumulation of rectum dose-volume metrics for prostate external beam radiotherapy combined with brachytherapy: evaluating deformably registered dose distribution addition using parameter-based addition
- Creator
- Moulton, Calyn R.; House, Michael J.; Lye, Victoria; Tang, Colin I.; Krawiec, Michele; Joseph, David J.; Denham, James W.; Ebert, Martin A.
- Relation
- Funding BodyNHMRCGrant Number300705 http://purl.org/au-research/grants/nhmrc/300705
- Relation
- Journal of Medical Imaging and Radiation Oncology Vol. 61, Issue 4, p. 534-542
- Publisher Link
- http://dx.doi.org/10.1111/1754-9485.12593
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2017
- Description
- Introduction: To investigate the accuracy of deriving dose-volume histogram (DVH) parameters from deformably registered data by comparing values with the simple addition of DVHs from each phase of a combined external beam radiotherapy (EBRT)/high-dose-rate (HDR-BT) brachytherapy prostate treatment. Methods: Eighty-two patients received EBRT in 23 fractions of 2 Gy and HDR-BT TG43 in three fractions of 6.5 Gy. The HDR-BT CT was deformably registered to the EBRT CT. The rectum D0.1cc, D1cc, D2cc and D10cc were calculated in two ways. (i) Parameter-adding: the EBRT DVH parameters (or the EBRT prescription dose) were added to the unregistered HDR-BT DVH parameters. (ii) Distribution-adding: the parameters were extracted after the EBRT doses were 3D-summed with the registered HDR-BT doses. Resulting differences between the parameters were investigated. Results: The D0.1cc, D1cc and D2cc from parameter-adding were 21.3% (P < 0.001), 6.3% (P < 0.001) and 3.5% (P < 0.001) smaller than those from distribution-adding. The D10cc was 2.2% (P=0.015) larger for distribution-adding. Conclusion: Distribution-adding was confounded by unsystematic inter/intra-observer rectum-contouring errors and registration accuracy near the anterior rectal wall. Consequently, clinical use of distribution-adding to assess rectal doses requires careful contour and registration evaluation.
- Subject
- brachytherapy; computer-assisted radiotherapy; computer-assisted radiotherapy planning; image-guided radiation therapy; prostate cancer
- Identifier
- http://hdl.handle.net/1959.13/1398997
- Identifier
- uon:34511
- Identifier
- ISSN:1754-9477
- Language
- eng
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