Synthesis and biological evaluation of bicyclic and tricyclic substituted nortropane derivatives: discovery of a novel selective alpha 1D-adrenergic receptor ligand

Title: Synthesis and biological evaluation of bicyclic and tricyclic substituted nortropane derivatives: discovery of a novel selective alpha 1D-adrenergic receptor ligand
Creator: McGinty, Susan J.; Finch, Angela; Griffith, Renate; Graham, Robert M.; Bremmer, John B.
Relation: Bioorganic and Medicinal Chemistry Vol. 12, Issue 21, p. 5639-5650
Publisher Link: http://dx.doi.org/10.1016/j.bmc.2004.07.063
Publisher: Elsevier Ltd.
Resource Type: journal article
Date: 2004
Description: A range of 3,6,6-trisubstituted nortropane derivatives based upon 6β-phenyltropane-3β,6 α-diol have been synthesised from 6β-hydroxytropinone, including some novel related tricyclic hemi-ketal and tricyclic ketal compounds. Derivatives were assessed for pharmacological affinity and selectivity at α₁-adrenergic receptors, and 6β-phenyl-8-azabicyclo[3.2.1]octan-3-spiro-2'-(1',3'-dioxolane)-6-ol, a novel lead compound selective for the alpha₁D-adrenergic receptor, is reported.
Subject: α₁-adrenergic receptor; 6β-hydroxytropinone; 3,6,6-trisubstituted nortropanes; microwave assisted reactions
Identifier: http://hdl.handle.net/1959.13/33971
Identifier: uon:3428
Identifier: ISSN:0968-0896
Language: eng
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