Tumor suppressor role of miR-503

Title: Tumor suppressor role of miR-503
Creator: Gupta, Gaurav; Chellappan, Dinesh K.; de Jesus Andreoli Pinto, Terezinha; Hansbro, Philip M.; Bebawy, Mary; Dua, Kamal
Relation: Panminerva Medica Vol. 60, Issue 1, p. 17-24
Publisher Link: http://dx.doi.org/10.23736/s0031-0808.17.03386-9
Publisher: Edizioni Minerva Medica
Resource Type: journal article
Date: 2018
Description: MicroRNAs (miRNAs) are noncoding RNAs of around 20-25 nucleotides in length with highly conserved characteristics. They moderate posttranscriptional silencing by precisely combining with 3' untranslated regions (UTRs) of target mRNAs at a complementary site. miR503, an associate of the "canonical" miRNA16 family, is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma and several others. There is convincing evidence to show that miR503 functions as a tumor suppressor gene through its effects on target genes that regulate cell proliferation, migration, and invasion in tumor cells. In this current assessment, we discuss the biology and tumor suppressor role of miR503 in different cancers and elaborate on its mechanism of action.
Subject: neoplasms; MIRN503 microRNA; genes, tumor suppressor
Identifier: http://hdl.handle.net/1959.13/1393676
Identifier: uon:33593
Identifier: ISSN:0031-0808
Language: eng
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