- Title
- Back to (non-)basics: an update on neutral and charge-balanced glycosidase inhibitors
- Creator
- Simone, Michela I.; Mares, Laura J.; Eveleens, Clothilde A.; McCluskey, Adam; Pappin, Brighid B.; Kiefel, Milton J.; Houston, Todd A.
- Relation
- Mini-Reviews in Medicinal Chemistry Vol. 18, Issue 10, p. 812-827
- Publisher Link
- http://dx.doi.org/10.2174/1389557517666171002161325
- Publisher
- Bentham Science Publishers
- Resource Type
- journal article
- Date
- 2018
- Description
- Glycosidases have important anti-cancer, anti-viral and anti-diabetic properties. This review covers the literature in the past 15 years since our initial review in this journal on “neutral” glycosidase inhibitors lacking a basic nitrogen found in iminosugars and azasugars or inhibitors that are neutral by virtue of being “charge-balanced” (zwitterionic). These structurally diverse inhibitors include lactones, lactams, epoxides such as cyclophellitol, and sulfonium ion derivatives of the natural product salacinol. Synthetic efforts toward cyclophillitol, salicinol and derivatives are also highlighted. Importantly, certain metals can inhibit glycosidases and care must be taken to remove residual catalysts from synthetic material to be tested against these enzymes.
- Subject
- cadmium; computational; glucocerebroside; glucosidase; glycal; homology; hydantocidin; iminosugar; lactam; lactone; mannosidase; metal complex; copper; modeling; molybdenum; natural product; palladium; salacinol; sialidase; silver; transition-state mimic; vanadium; x-ray crystallography; cyclophellitol; zinc; deoxynojirimycin; diabetes; electrophilic; epoxide; fucosidase; galactosidase
- Identifier
- http://hdl.handle.net/1959.13/1393431
- Identifier
- uon:33539
- Identifier
- ISSN:1389-5575
- Language
- eng
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