- Title
- Chronic stress induced disruption of the peri-infarct neurovascular unit following experimentally induced photothrombotic stroke
- Creator
- Zhao, Zidan; Ong, Lin Kooi; Johnson, Sarah; Nilsson, Michael; Walker, Frederick R.
- Relation
- Journal of Cerebral Blood Flow and Metabolism Vol. 37, Issue 12, p. 3709-3724
- Publisher Link
- http://dx.doi.org/10.1177/0271678x17696100
- Publisher
- Sage Publications
- Resource Type
- journal article
- Date
- 2017
- Description
- How stress influences brain repair is an issue of considerable importance, as patients recovering from stroke are known to experience high and often unremitting levels of stress post-event. In the current study, we investigated how chronic stress modified the key cellular components of the neurovascular unit. Using an experimental model of focal cortical ischemia in male C57BL/6 mice, we examined how exposure to a persistently aversive environment, induced by the application of chronic restraint stress, altered the cortical remodeling post-stroke. We focused on systematically investigating changes in the key components of the neurovascular unit (i.e. neurons, microglia, astrocytes, and blood vessels) within the peri-infarct territories using both immunohistochemistry and Western blotting. The results from our study indicated that exposure to chronic stress exerted a significant suppressive effect on each of the key cellular components involved in neurovascular remodeling. Co-incident with these cellular changes, we observed that chronic stress was associated with an exacerbation of motor impairment 42 days post-event. Collectively, these results highlight the vulnerability of the peri-infarct neurovascular unit to the negative effects of chronic stress.
- Subject
- stroke; chronic stress; neurovascular unit; glial cells; neuroinflammation
- Identifier
- http://hdl.handle.net/1959.13/1386961
- Identifier
- uon:32497
- Identifier
- ISSN:0271-678X
- Rights
- © 2017 Reprinted by permission of SAGE Publications.
- Language
- eng
- Full Text
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