- Title
- Oxidative stress, placental ageing-related pathologies and adverse pregnancy outcomes
- Creator
- Sultana, Zakia; Maiti, Kaushik; Aitken, John; Morris, Jonathan; Dedman, Lee; Smith, Roger
- Relation
- American Journal of Reproductive Immunology Vol. 77, Issue 5, no. e12653
- Publisher Link
- http://dx.doi.org/10.1111/aji.12653
- Publisher
- Wiley-Blackwell Publishing
- Resource Type
- journal article
- Date
- 2017
- Description
- Oxidative stress (OS), an imbalance between free radical generation and antioxidant defence, is recognized as a key factor in the pathogenesis of adverse pregnancy outcomes. Although OS is a common future of normal pregnancy, persistent, overwhelming OS leads to consumption and decline of antioxidants, affecting placental antioxidant capacity and reducing systems. The accumulation of OS causes damage to lipids, proteins and DNA in the placental tissue that induces a form of accelerated ageing. Premature ageing of the placenta is associated with placental insufficiency that prevents the organ meeting the needs of the foetus, and as a consequence, the viability of the foetus is compromised. This review summarizes the literature regarding the role of OS and premature placental ageing in the pathophysiology of pregnancy complications.
- Subject
- intrauterine growth restriction; oxidative stress; placental ageing; pre‐eclampsia; preterm birth; senescence; stillbirth
- Identifier
- http://hdl.handle.net/1959.13/1384527
- Identifier
- uon:32096
- Identifier
- ISSN:1046-7408
- Rights
- This is the pre-peer reviewed version of the following article: Sultana Z, Maiti K, Aitken J, Morris J, Dedman L, Smith R. Oxidative stress, placental ageing‐related pathologies and adverse pregnancy outcomes. Am J Reprod Immunol. 2017;77:e12653, which has been published in final form at https://doi.org/10.1111/aji.12653. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
- Language
- eng
- Full Text
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