- Title
- Ganaxolone: a new treatment for neonatal seizures
- Creator
- Yawno, Tamara; Miller, Suzie L.; Bennet, Laura; Wong, Flora; Hirst, Jonathan J.; Fahey, Michael; Walker, David W.
- Relation
- Frontiers in Cellular Neuroscience Vol. 11, Issue August 2017, no. 246
- Publisher Link
- http://dx.doi.org/10.3389/fncel.2017.00246
- Publisher
- Frontiers Research Foundation
- Resource Type
- journal article
- Date
- 2017
- Description
- Neonatal seizures are amongst the most common neurologic conditions managed by a neonatal care service. Seizures can exacerbate existing brain injury, induce “de novo” injury, and are associated with neurodevelopmental disabilities in post-neonatal life. In this mini-review, we present evidence in support of the use of ganaxolone, a GABAA agonist neurosteroid, as a novel neonatal therapy. We discuss evidence that ganaxolone can provide both seizure control and neuroprotection with a high safety profile when administered early following birth-related hypoxia, and show evidence that it is likely to prevent or reduce the incidence of the enduring disabilities associated with preterm birth, cerebral palsy, and epilepsy. We suggest that ganaxolone is an ideal anti-seizure treatment because it can be safely used prospectively, with minimal or no adverse effects on the neonatal brain.
- Subject
- neurosteroids; ganaxolone; phenobarbitone; neonatal seizures; hypoxic-ischemic encephalopathy; neuroprotection
- Identifier
- http://hdl.handle.net/1959.13/1355636
- Identifier
- uon:31504
- Identifier
- ISSN:1662-5102
- Rights
- © 2017 Yawno, Miller, Bennet, Wong, Hirst, Fahey and Walker. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Language
- eng
- Full Text
- Reviewed
- Hits: 6738
- Visitors: 7121
- Downloads: 494
Collections
Goal 3: Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 341 KB | Adobe Acrobat PDF | View Details Download |