- Title
- Chronic stress-induced changes in microglia in determining vulnerability to mood disorders
- Creator
- Walker, Frederick Rohan; Ong, Lin Kooi; Nilsson, Michael
- Relation
- The Primer Of PsychoNeuroImmunology Research p. 119-124
- Relation
- https://pnirs.org/primer/index.cfm
- Publisher
- PsychoNeuroImmunology Research Society
- Resource Type
- book chapter
- Date
- 2016
- Description
- Chronic stress has long been recognised to be a major risk factor in the emergence of mood disorders and in particular major depression. Due to this association a wealth of pre-clinical information has emerged over recent decades describing the myriad of changes that stress exposure can provoke within the brain. While it is impossible to synthesize this research it would be fair to say that the research into the neurobiology of depression has undergone several major shifts in focus. Early efforts, in line with the prevailing monoaminergic hypothesis of depression, closely examined how stress altered pre- and postsynaptic serotonergic transmission. This was soon followed by a major effort to link mood disturbance to pathological alterations within the stress-signalling apparatus and in particular the hypothalamic pituitary adrenal (HPA) axis. More recently, and following closely several remarkable discoveries concerning the rapid antidepressant actions of ketamine, interest turned to glutamatergic and purinergic signalling.
- Subject
- mood disorders; chronic stress; depression; neurobiology; serotonergic transmission
- Identifier
- http://hdl.handle.net/1959.13/1346838
- Identifier
- uon:29939
- Identifier
- ISBN:9780692708293
- Language
- eng
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