Biochemical alterations in the oocyte in support of early embryonic development

Title: Biochemical alterations in the oocyte in support of early embryonic development
Creator: Martin, Jacinta H.; Bromfield, Elizabeth G.; Aitken, R. John; Nixon, Brett
Relation: Cellular and Molecular Life Sciences Vol. 74, Issue 3, p. 469-485
Publisher Link: http://dx.doi.org/10.1007/s00018-016-2356-1
Publisher: Springer
Resource Type: journal article
Date: 2017
Description: Notwithstanding the enormous reproductive potential encapsulated within a mature mammalian oocyte, these cells present only a limited window for fertilization before defaulting to an apoptotic cascade known as post-ovulatory oocyte aging. The only cell with the capacity to rescue this potential is the fertilizing spermatozoon. Indeed, the union of these cells sets in train a remarkable series of events that endows the oocyte with the capacity to divide and differentiate into the trillions of cells that comprise a new individual. Traditional paradigms hold that, beyond the initial stimulation of fluctuating calcium (Ca²⁺²⁺ release and the suite of molecular modifications that sweep through the oocyte to ensure the successful union of the parental germlines and ensure embryogenic fidelity.
Subject: zygote; oocyte activation; phosphorylation; protein kinase; DNA repair; DNA protection
Identifier: http://hdl.handle.net/1959.13/1345402
Identifier: uon:29633
Identifier: ISSN:1420-682X
Language: eng
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