- Title
- Omega-3 polyunsaturated fatty acids and hyperlipidaemias
- Creator
- Ferguson, J. J. A.; Dias, C. B.; Garg, M. L.
- Relation
- Omega-3 Fatty Acids: Keys to Nutritional Health p. 67-78
- Publisher Link
- http://dx.doi.org/10.1007/978-3-319-40458-5_6
- Publisher
- Springer International
- Resource Type
- book chapter
- Date
- 2016
- Description
- Hyperlipidaemia is a multifaceted risk factor for cardiovascular disease, involving multiple aetiologies such as diet, lifestyle, and/or metabolic effects within the body. Dietary long-chain omega-3 polyunsaturated fatty acids (n-3PUFA) have been shown to regulate key pathways involved in lipid metabolism. By this action, n-3PUFA favourably modulate blood lipids such as triglycerides (TG), low-density lipoproteins (LDL), and high-density lipoproteins (HDL). The hypolipidaemic effects of dietary supplementation with n-3PUFA may be enhanced by combination drug or natural therapies and have the potential to reduce dependence on lipid-lowering drug therapy. The widespread modulatory effects on blood lipid profile are not only dose dependent, but also dependent on genetic make-up and gender differences. Further investigation into the modulatory effects of dietary n-3PUFA on blood lipids is warranted in order to optimize the efficacy of n-3PUFA therapy for the prevention and management of hyperlipidaemias. Future studies should investigate the influence of gender and genotypic variants on the effects of dietary n-3PUFA in order to optimize dietary strategies and recommendations to prevent and manage hyperlipidaemias.
- Subject
- omega-3 polyunsaturated fatty acids; Α-linolenic acid; triglycerides; docosahexaenoic acid; eicosapentaenoic acid; hyperlipidaemia; lipids; total cholesterol; very low-density lipoprotein; low-density lipoprotein; high-density lipoprotein
- Identifier
- http://hdl.handle.net/1959.13/1344927
- Identifier
- uon:29529
- Identifier
- ISBN:9783319404585
- Language
- eng
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